NewLimit is building a novel platform to discover epigenetic reprogramming therapies at industrial scale.
NewLimit was founded to cure aging. We are working toward this goal by uncovering sets of transcription factors that can epigenetically reprogram cells. Although our products are designed to treat aging itself, we also believe these products could treat or prevent many diseases associated with aging, including fibrosis, infectious disease, and neurodegenerative disease.
This new funding is in addition to the founders’ original $110 million commitment to the company. With the additional capital we plan to remain a small focused team where everyone contributes to the line work and everyone contributes to company building. There are no shortcuts.
Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.
Known for identifying cutting edge technologies, he is currently a Co-Founder of a startup and fundraiser for high potential early-stage companies. He is the Head of Research for Allocations for deep technology investments and an Angel Investor at Space Angels.
A frequent speaker at corporations, he has been a TEDx speaker, a Singularity University speaker and guest at numerous interviews for radio and podcasts. He is open to public speaking and advising engagements.
Well, yes. If we could address aging as a disease, and cure it or suspend it, and possibly even counter it with regenerative rejuvenation, it would be drastically efficacious in reducing, but not eliminating, the need to deal with all the attendant ills of old age.
Not convinced that one could really consider aging a disease – but I get the benefit with the FDA and allowing significant pharma and medical development. As with any machine, the surrounding environment will simply break down the body, like rust, rot, and oxidation on engineering materials. Even the self-healing mechanisms deteriorate and fail. The bottom line is that the human body parts have a shelf life and their coordinated failure mean the failure of the whole – even by over-clocking the fixers. Without replacement, upgrade, and/or fundamental re-design, the human body is only optimally functional, optimistically, for a bit more than a century. Why people cling to preserving their delicate and functionally mediocre form rather than push along a cybernetic/ brain upload/ augmentation path is beyond me.
Not sure how you can’t consider treating aging as a disease in 2023.
It is time that therapies were developed and deployed to focus on the root cause of disease instead of treating symptoms.
Well, we do manage to keep some of our cells in tip top working order. Cells required for reproduction have to be, otherwise our children would be born old. These cells have been kept alive and young for billions of years. So it can be done.
Takes a lot of repairs, and a serious inspection and screening process, but it has been done and it has been done for a long time, therefore it is doable.
There is apparently a high energy cost for this and, evolution being a bit of cheapskate (with little regard for individuals, only the species), the rest of our cells are disposable. Unfortunately, the part of our bodies that we count as being us (brains especially) are among the parts that evolution determined could be discarded periodically, rather than expending the effort and energy required to keep them young.
Evolution does not care about us as individuals, not even when the individuals are thinking they would rather not deteriorate and die, even after they have adequately reproduced.
We can’t even refer to human aging as planned-obsolescence as it is not planned, it just happens because there was insufficient impetus to favor evolving beyond it. In other words, it happens because human evolution has never had an incentive for eliminating it. There are also hints at this in that, when under stress, human cells will often devote more resources to repair, rather than reproduction, slightly extending potential lifespans.
But, given that obesity is actually killing people, it would seem we would now eagerly pay the energy price to keep all or most of our cells in young (undamaged) state. And folks are working on how we can do this, along with many other strategies. It seems highly likely they some of these efforts must eventually bear fruit.
And yes, I don’t doubt that eventually we may even choose to replace our cells with new and improved synthetic cells (nano-machines) when the tech is good enough, blurring the line between organic and inorganic.
This would also likely make things like recording and copying our minds themselves possible (our organic legacy design bodies just don’t have a very good I/O interface for that sort of thing). It might also open the door to redesigning our minds to be better, possibly multi-threaded, and/or even running in parallel networked instantiations. At some point it even seems possible, perhaps likely, that we would design and construct our children, rather than throwing some chemical DNA samples against each other to see what happens, but who can say? There will likely always be off-grid folks around, as they would be considered desirable as a control group, and possibly an ethics test, if nothing else. But I think simpler, more organic forms of radical life extension will precede these kind of methods.