Underestimating Life Expectancy Improvements on Insurance Policies

General Electric has recently been accused of accounting fraud for not properly reporting the cost of providing Long Term Care to old people on insurance policies sold many years ago.

All of the insurance companies that sold long-term care insurance have larger than previously expected expenses because decades ago they failed to anticipate the increase in life expectancy from 75 years to the over 80 years for many people.

The previous gains to longevity also tended to increase the number of years where someone was sick.

We could be on the verge of another demographic surprise where antiaging provides larger gains to lifespan. The new increases in longevity could come with vastly longer healthspan. We should stay healthier far longer. The period of time that we will be sick will be difficult to predict.

For at least the next, ten to fifteen years, people who want to apply lifestyle and medicine to apply the latest research in antiaging it will mostly be do-it-yourself. People will have to seek out open-minded doctors if they need certain prescriptions. There will also be options in terms of overseas pharmacies and clinics. Clearly, these options can have some more risks than working within the medical system. However, people have already used these alternative options for lower cost access to drugs like Viagra and Cialis.

How Many Will Go For the New Antiaging Options? Perhaps 1% have gone for comprehensive diet and exercise lifestyles that can add 7 years to lifespan. About 80% of the world does not smoke. About 85% of the US population does not smoke. 70% of the world is not obese.

The number of people following and sustaining the calorie restriction diet is perhaps only a few tens of thousands. There are far more trying the various forms of intermittent fasting.

There are some early antiaging drugs and supplements which seem to have some scientific evidence of some effectiveness. Those are metformin, NAD+ and other drugs.

Some studies indicate that metformin is half as effective as aggressive lifestyle management.

Lifestyle Modification

There are various diet and lifestyle modifications which can enable people to have a 1 in 2 chance to live to about 88 instead of 80 for men or 83 for women.

There a few million people who follow the Seventh-day Adventist lifestyle. There are other populations and lifestyles like the Okinawa diet.

There were a few roughly 30,000 person Seven-day Adventist participated in few health studies.

On average Adventist men live 7.3 years longer and Adventist women live 4.4 years longer than other Californians.

Five simple health behaviors promoted by the Seventh-day Adventist Church for more than 100 years (not smoking, eating a plant-based diet, eating nuts several times per week, regular exercise and maintaining normal body weight) increase life span up to 10 years.

* Reducing consumption of red and white meat was associated with a decrease of colon cancer.
* Eating legumes was protective for colon cancer.
* Eating nuts several times a week reduces the risk of heart attack by up to 50%.
* Eating whole bread instead of white bread reduced non-fatal heart attack risk by 45%.
* Drinking 5 or more glasses of water a day may reduce heart disease by 50%.
* Men who had a high consumption of tomatoes reduced their risk of prostate cancer by 40%.
* Drinking soy milk more than once daily may reduce prostate cancer by 70%.

Senolytics Drugs to Remove Senescent Cells

Senolytics Drugs extend the lifespan of mice by about 35% and newer drug protocols might achieve a 50% increase in mice lifespan.

For those who do not want to wait for Senolytics Drugs from biotech companies. There is an early adopter option.

Bill Faloon is the co-founder of the Life Extension nutritional supplement company and founder of the Church of Perpetual Life in Hollywood, Florida.

Bill was at the Raadfest 2018, which is an antiaging conference which had an attendance of about 1000 people. Bill is like others who attend Raadfest who want to take any antiaging treatment which has some scientific evidence of effectiveness. There is the possibility that latest antiaging treatments could work and the early adopters might be able to improve their health and life 0 to 20 years longer.

Bill personally takes about 100 pills per day with the objective of extending his own life.

Bill is on a calorie restricted diet with intermittent fasting and is taking Metformin.

He also takes hormones and DHEA hormones. He has NAD+ infusions and is taking the Dasatinib-Quercetin drugs to remove senescent cells.

There is research that combining Dasatinib, a chemotherapy drug, with Quercetin, a plant flavonol can extend life. Taken together in clinical trials, the drug cocktail was shown to extend the life of lab mice by 36 percent.

The Dasatinib-Quercetin treatment was new for 2018. Bill and his team worked out what they believe is the correct twice a year dosage based on your weight. The dosage levels are shown below. Bill indicated that others who want to agressively adopt the latest anti-aging treatment can pay about $200 for a compounding pharmacy to provide the Dasatinib. A doctor’s prescription is needed.

AgeX Inducing Regeneration and Other Stem Cell Work

Nextbigfuture has had recent interviews with Dr. Michael West and Aubrey de Grey of AgeX.

AgeX is looking to apply stem cells and gene therapy-induced and telomerase tissue regeneration for antiaging.

Gene Therapy for Aging Reversal

George Church revealed progress on aging reversal using gene therapies. They have delivered 45 gene therapies to provide aging reversal. They find the combined treatment is effective against obesity, diabetes, osteoarthritis, cardiac damage and kidney disease.

The peer-reviewed paper on the age-reversing combination gene therapy should be published this year. There has been the rumor that the existing age-reversing combination gene therapy extended the lifespan of mice by 100%. This would be triple the effect of calorie restriction. If it was successfully applied to humans and had the same

At 32:00-33:30 minutes George Church specifically describes delivering 45 age-reversing gene therapies to treat multiple age-related diseases.

This is the work that Nextbigfuture has been expecting from George’s company Rejuvenate Bio.

Rejuvenate Bio has been using the aging reversal therapies on dogs for almost all of 2018.

George Church expects to get the treatment to people around 2025.

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