• High-throughput screening identified specific small-molecule PAPD5 inhibitor BCH001
• BCH001 restores telomere length in iPSCs from patients with dyskeratosis congenita
• Repurposed HBsAg suppressors, dihydroquinolizinones, increase TERC in stem cells
• Oral PAPD5 inhibitors restore TERC and telomeres in human HSPCs in vivo
They tested more than 100,000 known chemicals. They got 480 initial “hits,” which they ultimately narrowed to a small handful.
they were able to boost the cells and restore telomere length.
Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.
Known for identifying cutting edge technologies, he is currently a Co-Founder of a startup and fundraiser for high potential early-stage companies. He is the Head of Research for Allocations for deep technology investments and an Angel Investor at Space Angels.
A frequent speaker at corporations, he has been a TEDx speaker, a Singularity University speaker and guest at numerous interviews for radio and podcasts. He is open to public speaking and advising engagements.