Large Mouse Study Still Tracking to Experimentally Doubling Remaining Life of Middle Age Male Mice

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The all-treatments group is still taking roughly twice as long as the all-controls group (starting from 19 months old, when the experiment began) to get down to a given survival percentage in males. The all treatments female mice are lasting 50% longer than controls. It’ll still be a few months before we can start to discern whether this persists well enough to constitute the Holy Grail of a true lengthening of mortality rate doubling time.

What does this mean for humans? Rapamycin and calorie restriction has had quite a bit of research. Rapamycin and calorie restriction may provide an average of about 2-5 years of added life. The combination treatments could be about 50% better than just Rapamycin. This would mean 3-8 years of added life. However, the studies on humans have not been made for a long enough time to know this with certainty. This is information from incomplete studies of only a decade or so.

There have been different life extension therapies where each on there own can add about 10-35% to the remaining life of a mouse. Here we are seeing if combining four of the best therapies can double the expected remaining life of a middle age mouse from one year to over two years. The male mice in the 1000 mouse study are tracking closely to doubling the remaining life of the mice.

Those four interventions are:
* Senescent cell ablation via galactose-conjugated Navitoclax (“Nav-Gal”) [removing old cells]
* Rapamycin in food at 42 ppm [calorie restriction mimick]
* Enhanced telomerase expression via repeated TERT gene therapy (via nasally administered AAV-mTERT) [extending the ends of DNA]
* Hematopoietic stem cell transplantation [adding young cells]

Senescent cells are zombie (aka malfunctioning) cells.

11 thoughts on “Large Mouse Study Still Tracking to Experimentally Doubling Remaining Life of Middle Age Male Mice”

  1. mammal brains are fundamentally incapable of functioning more than 120 years anyway

    if nothing else gets you by then, Alzheimer’s will

    we are all born with a certain number of synaptic firings

    just like the eggs, they run out over time

    human brains are somewhat unusual in having evolutionary value even after the eggs are gone

    so our synaptic firing lasts quite a bit longer

    but sadly it appears there’s only so many of either

    still there’s a lot to be said for quality of life

    after five years of fasting I probably added only a week to my probability-adjusted lifespan

    but oh the quality

  2. I think there’s a difference between a mouse living one more year, and a human living 40-80 more years.

  3. >Doubling Remaining Life of Middle Age Male Mice

    Please compare the ‘snake oil’ treatment to simply maximizing the lifestyle of the mouse (weight control, rest, stress free yet stimulating environment, lots of sexual partners, etc.)

  4. Unfortunately it doesn’t translate very well in humans. Or else we would see 120+ years old humans living today.

    My guess is that you will have to reduce damage by 80% in at least 3-4 type of damage to live 20 years longer.

    • Why would we see humans live to 120 when the treatment has not been administered to humans yet???

    • mammal brains are fundamentally incapable of functioning more than 120 years anyway

      if nothing else gets you by then, Alzheimer’s will

      we are all born with a certain number of synaptic firings

      just like the eggs, they run out over time

      human brains are somewhat unusual in having evolutionary value even after the eggs are gone

      so our synaptic firing lasts quite a bit longer

      but there’s only so many of either

  5. I’d love to know what the mice think about this, but how it translates to humans (IMO) is still a big open question. We need to do studies in humans (ethically of course) to get actionable results.

  6. Lucky mice.
    I’d love a concoction that doubles my life…with UBI of course, I don’t want to work until I’m 100, I’m 40 and my knee hurts somedays.

  7. I think a lot of these mouse studies have to be interpreted with a very high degree of caution. One major difference between spf mice and humans is herpesvirus latency. Laboratory mice have none. There is a murid herpesvirus that can infect them when given experimentally but most are negative. This contrasts with humans who have 6-8 herpesviruses acquired through young adulthood. Most of the time you don’t notice. Until your immunity wanes and you get viral reactivation like during shingles. Suckinical reactivation may drive more inflammation and aging. I think that is why many of these regimens have limited effects in non spf (specific pathogen free)animals

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