Aubrey de Grey has been leading the charge to fix damage from aging for over twenty years. He has been interviewed on Joe Rogan, 60 Minutes and many other shows. He has developed and championed the concept of repairing the seven known categories of aging damage as the way to get to comprehensive aging reversal.
In this talk with Aubrey de Grey, we get his unique and comprehensive overview of the current view of the field of aging repair, cancer treatments and brain repair. He gives the historical and scientific context. He talks about some of the most promising companies in the vibrant field of antiaging.
Aubrey created and led the SENS (anti-aging) institute and it has had over $50 million in funding over the past 20 years. They also got six antiaging companies funded and spun out. He is at the center of the 158+ company anti-aging industry.
Sections:
01:00 Aubrey corrects mistaken aging beliefs
06:30 Next Level Funding for Aging has been reached $10B+
07:50 Trends and new developments
17:30 High confidence of first generation comprehensive treatments by 2035
23:00 Science of epigenetic modification for aging intervention
30:45 THIO anticancer treatment
36:05 Getting aging treatments affordably to everyone, Pandemic response evidence
41:55 Alphafold 2 Protein folding solution and AI acceleration of Aging research
52:00 New tests and tech can revolutionize early detection
55:35 Scaling treatments, the example of Parkinsons
1:01:00 TAME Trial and an FDA accepted definition of aging
1:05:00 Global efforts against aging
1:09:00 Antiaging Conferences
1:13:00 Early adopters of antiaging treatments and personal risk tolerance
Aubrey de Grey has been leading the charge to fix damage from aging for over twenty years. He developed and championed the concept of repairing the seven known categories of aging damage as the way to get to comprehensive aging reversal.
In this talk with Aubrey de Grey, we get his unique and comprehensive overview of the current view of the field of aging repair, cancer treatments and brain repair. He gives the historical and scientific context. He talks about some of the most promising companies in the vibrant field of antiaging.
Aubrey created and led the SENS (anti-aging) institute and it has had over $50 million in funding over the past 20 years. They also got six antiaging companies funded and spun out. He is at the center of the 158+ company anti-aging industry.
Aubrey also had an early career in Artificial Intelligence. Part of this interview digs into his insights about recent AI developments and how it will be applicable to successfully developing antiaging,
His current favorite company and approach for a broadly applicable treatment for cancer is at Maia Biotechnology.
Maia is using a telomere approach. THIO is a potentially first-in-class small molecule that is the only direct telomere targeting agent currently in clinical development. Telomerase is present in over 85% of human cancers and contributes significantly to the proliferation and reproductive immortality of cancer cells. THIO’s in vitro activity has been studied in models of several tumor types with active telomerase.
Having comprehensive treatments for all types of aging damage and new treatments for cancer and brain repair will create a new age of health and medicine. Winning companies in the areas of antiaging, cancer treatment and brain repair could become trillion-dollar biotech giants.
Over Twelve Billion Dollars have been invested in nearly 200 companies working on real aging cures. There is $2-4 billion in new investments in aging cures every year. The rate of scientific progress toward fixing aging is no longer money limited.
Here is a link to Karl Pfleger’s list of 158 antiaging companies. Karl used to work at Google and has been an active angel investor in antiaging companies.
The global response to the COVID pandemic to develop many vaccines and treatments shows that the world will develop aging treatments and make them inexpensive or free treatments for everyone.
Aubrey is also very hopeful about a company with an exciting approach to preventing or treating most types of cancer.
Have you ever thought about adding a little bit more than just your
articles? I mean, what you say is fundamental and all. However imagine if you
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more, “pop”! Your content is excellent but with images and video clips, this website could undeniably be one of the greatest in its field.
Good blog!
You’ve never seen one of Brian’s articles, have you?
promises, promises… have been hearing these for the last 30 years and still nada…
Well, finally saw the video. A lot of promising developments lately, and at 63, *maybe* I’ll actually benefit from some of them, since it sounds like some would actually reverse aging, not just slow it down.
On the funding point: It’s my expectation that, if a good but expensive rejuvenation therapy becomes available, the government might find it economical to offer a trade to elders: They’ll pay to make them young again, in return they lose their old age pensions and have to go back to work. What’s certainly the case is that the advent of these therapies will make a lot of defined benefit pension plans, that count on the recipients dying shortly after qualifying, totally uneconomical.
You’ve only got to make it to the point at which they halt ageing, then you’ve got all the time in the world to wait out age reversal. It might be an uncomfortable decade or two, but your time will come again.
If he ever walks out to podium for a presentation looking like he is twenty years old, nobody will be able to hear anything he says because it will be drowned out by the wind from all the credit cards being waved at him.
Yes many people are taking on the epigenetic view of ageing but recently there was quite a remarkable paper showing how mutation rates, i.e. real changes in DNA bases as apposed to epigenetic modifications, correlate with a broad range of species life-spans. One could potentially argue that epigenetic disfunction may be causing the increased mutation rates but the other way around is just as, if not more, plausible. That would mean ageing could turn out to be a much harder problem than we think.
There’s no question that aging is a really, really tough nut to crack. I fact, I suspect that we’ll eventually have to redesign our whole biology if we want to comprehensively solve the problem. Or perhaps integrate some degree of molecular nanotech that can actively fix things, supplementing the biology. The SENS foundation claims that they’ve found a limited set of causes of aging, and that fixing them would stop it in its tracks, but really, they’ve only identified the problems we currently live long enough to encounter. Once the current causes are solved, we’ll encounter new problems that need fixing. Like loss of long range connectivity in the brain as foundational nerve cells die from cosmic ray strikes.
But… With each advance, we gain more time to find the next. We don’t actually have to solve the whole problem at once.
Well, as a species we don’t. I’m in my 60’s, I’m probably just screwed, by the time this stuff actually makes it out of clinical trials I’ll probably have one foot in the grave already. I console myself that at least my son won’t have to experience having his body and brain rotting away while he’s still alive.
Poor Alan Harrington; He didn’t quite live long enough to see that war on death he advocated declared, and the troops mobilized.
Saudi Arabia throws its hat into the ring:
Saudi Arabia plans to spend $1 billion a year discovering treatments to slow aging
https://www.technologyreview.com/2022/06/07/1053132/saudi-arabia-slow-aging-metformin/
Funny that the guy that has dedicated his life to fight aging, has always looked much older than he is.
But hey, probably it’s by choice, or people would start complaining about he starting to look old. So the sooner the better.
I agree, Hugh Jackman really let himself go.
You are wrong, he looked youthful for his age for a long tíme. If you think he’s starting to show signs and aging finally then he is still probably older than he looks.
The video is unavailable, marked “private”.
Is it still showing that? I have it set to public
Works ok now, thx Brian