Lifespan.io reports that researchers have reduced memory and learning symptoms in mice. Alzheimer’s research needs new approaches. A paper describes a promising molecule built using a technique that can be expanded to numerous other proteins with post-translational modifications. The researchers were also able to deliver the rather large molecule intranasally across the blood-brain barrier, alleviating …
Aubrey De Grey gave a kickoff announcement for the new Robust Mouse Rejuvenation study. Above- Just a random picture of mice, not the mice in this study. The study just has a few hundred ordinary mice that have not had anything special so far. The Robust Mouse Rejuvenation” study that LEVF (Longevity Escape Velocity Foundation) …
Dr. Daniel Kraft explores the past and future of technology-enabled health and biomedicine and premiers Digital.Health, a new platform for exploring and leveraging existing digital health solutions. For more on the future of health and medicine, join Daniel at NextMed.Health a unique, cross-disciplinary program exploring the cutting edge and future of health(care). Brian WangBrian Wang …
Rejuvenate Bio systemically delivered AAVs (gene therapy delivered via altered virus shells), encoding an inducible OSK system, in 124-week-old mice extends the median remaining lifespan by 109% over wild-type controls and enhances several health parameters. Treated mice lived another 18 weeks, on average, while control mice died in nine weeks. This was a doubling of …
Researchers developed a system called “ICE” (inducible changes to the epigenome) in DNA reparation, which actually advances aging, and also discovered that the process can be reversed by using OSK-mediated rejuvenation. Using the ICE system, young mice have aged quickly, but with dire consequences on the tissues in their bodies. Journal Cell – Loss of …
Aubrey de Grey announced the expansion of the SenoSTEM project. SENS had the SenoSTEM project. The biggest project of Aubrey’s new foundation will be testing combination antiaging therapies. This is taking antiaging therapies that are beneficial by themselves and using them in combination to hopefully achieve better results. There is a “parabiosis on steroids” project. …
Aubrey de Grey spoke at his Longevity Summit Dublin conference. He has created a new antiaging foundation. They will combine stem cells and senolytic interventions. They will partner with iChor. IChor’s lab is able to perform large mouse studies. They will be able to test many other combinations of aging damage interventions. They will perform …
The leader of the Antiaging movement, Aubrey de Grey, has started a new antiaging foundation. The new foundation will be advancing combination antiaging damage repair therapies. The new foundation will work with Ichor Life Sciences. Ichor spun out of Aubrey’s prior foundation. Ichor has macular regeneration work and has expanded to senenscent cells and acts …
Rejuvant AKG had an average 7 month study on people and it reversed 8 years of biological age according to methylization biomarker clocks. This work needs to be validated with more studies. The time released combination of Calcium and Alpha-Ketoglutarate in Rejuvant’s LifeAKG™ seems to reset methylation patterns in your DNA. However, there needs to …
Japanese researchers have made progress on an exercise pill. The exercise pill is a drug that mimics the effect of exercise on muscle and bone. They want to provide this for people who are bedridden or otherwise unable to exercise. LAMZ augments muscle and bone by mimicking calcium signaling to induce PGC-1α. Schematic of LAMZ …
The Great Age Reboot is the concept developed by leading longevity practitioner, Michael Roizen, M.D. (Dr. Mike), Emeritus Chief Wellness Officer at the Cleveland Clinic and best-selling author. Roizen believes that sometime in the next 10 years, you are going to be able to—because of the exponential advances in 14 areas of aging mechanism research—reboot …