Antiaging Gene Therapies Extend Lifespan of Mice by 41%

Antiaging gene therapies to overexpress TERT and Follistatin were used in a mouse model. The mice saw a 41 and 32% increase in median life span. The study also used a novel viral vector, cytomegalovirus for the delivery. Liz Parish of Bioviva has treated herself with all of these antiaging gene therapies. If humans experienced …

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Anti-aging Protein in Blood Cells Helps Slow Cognitive Decline

As life expectancies around the world increase, so are the number of people who will experience age-related cognitive decline. The amount of oxygen in the blood declines with age. Aging in the brain might be naturally held at bay by adenosine receptor A2B (ADORA2B), a protein on the membrane of red blood cells which is …

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How the World Defeats Aging by 2035 – Aubrey de Grey Interview

Aubrey de Grey has been the leading voice for antiaging, aging reversal and aging damage repair for over twenty years. He founded the SENS non-profit (Strategies for Engineered Negligible Senescence (SENS). There have been six antiaging companies that have been directly spun out of SENS. SENS is researching the hardest problems related to fixing aging …

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Scientific Progress to Radical Antiaging, Aubrey Sees 50+% of Longevity Escape Velocity by 2035

Antiaging expert Aubrey de Grey says antiaging science is considerably closer to robust mouse rejuvenation than we were 10 years ago and the gap between the achievement of robust mouse rejuvenation and the achievement of robust human rejuvenation is also coming down quite fast. Aubrey de Grey is the co-founder of the SENS research foundation …

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Comparing the Life Extension Era with the Pre-Life Extension Era

Life extension has been happening for over 100 years. It doubled in the UK from 40 years to 80 years from 1850 to 2015. It has almost tripled in India from 24 to 69 from 1920 to 2015. An article written by Matthew Bacher on increasing life expectancy is like many other articles that do …

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Rapid Aging Reversal Achieved With Human Cells

Transient reprogramming, mediated by transient expression of mRNAs, promotes a rapid reversal of both cellular aging and of epigenetic clock in human fibroblasts and endothelial cells, reduces the inflammatory profile in human chondrocytes, and restores youthful regenerative response to aged, human muscle stem cells, in each case without abolishing cellular identity. Old human cells can …

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George Church and Rejuvenate Bio’s Combination Gene Therapy Paper

Nextbigfuture has been eagerly awaiting the publication of the research paper on the scientific results of the combination gene therapy experiments by George Church and the team at Rejuvenate Bio. There was a video over one year ago where George Church mentioned being able to double the lifespan of mice. This would be three times …

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Rapamycin and Two Other Drugs Extends Lifespan Twice As Much As Any Other Drug Combo

A triple drug combination has been used to extend the lifespan of fruit flies by 48% in a new study led by UCL and the Max Planck Institute for Biology of Aging. The three drugs are all already in use as medical treatments: lithium as a mood stabilizer, trametinib as a cancer treatment and rapamycin …

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