David Sinclair is working on various anti-aging molecules. He was famous for discovering the anti-aging effect of resveratrol and sirtuins. David Sinclair was interviewed on the Joe Rogan show about antiaging. In 2013, GlaxoSmithKline shutdown Sirtris (David Sinclair’s company) about five years after spending $720 million to buy Sirtris. David A. Sinclair, Ph.D., A.O. is …
People worry about overpopulation because they have not looked into how food, family size, and money work. They have no basic understanding of numbers. I have researched this stuff a LOT but I think I can it make it fairly simple. The doomers use “the people numbers are big – we can’t feed them”. People …
The oldest giant tortoises are revealing their genetic secrets for living up to 250 years. They are animals that are in the range of human size. Female giant tortoises are about 250 pounds and male giant tortoises are about 500 pounds. There are other super long-lived creatures like whales and sharks. However, those larger creatures …
Goldman Sachs analysts asked “Is curing patients a sustainable business model?” analysts ask in an April 10 report entitled “The Genome Revolution.” Goldman was addressing the question of gene therapies that provide complete cures with one treatment. “The potential to deliver ‘one shot cures’ is one of the most attractive aspects of gene therapy, genetically-engineered …
In 2001, Aubrey de Grey and colleagues proposed ablation of senescent cells (ApoptoSENS) as the “damage-repair” strategy of choice for zombie cells. The idea was barely mentioned in the scientific literature. It was largely ignored until 2011 when a powerful proof-of-concept study showed that killing these “zombie cells” using a genetically-engineered “suicide switch” substantially rejuvenated …
Dr. James Peyer of ApolloVC discussed tactical paths to bring longevity promoting therapeutics to market as quickly as possible. The cost of developing a drug is $2.6 billion. Pharma companies need to have each successful drug approved has to pay for ten failed drugs. Each drug from discovery through clinical trials averages out to a …
Unity Biotechnology is a biotech leader in developing treatments to eliminating accumulated senescent cells, which are a fundamental mechanism of aging and a driver of many common age-associated diseases. Senescent cells normally destroy themselves via a programmed process called apoptosis, and they are also removed by the immune system; however, the immune system weakens with …
Mayo Clinic anti-aging researcher James Kirkland published about a drug combination that can slow and reverse senescent cells in mice. A leukemia drug dasatinib and the dietary supplement quercetin reduced senescent cells’ numbers, tamped down the inflammation they cause, and reduced the level of disability that comes with age-related diseases. The drugs delayed age-related diseases. …
Auctus Biologics, a new portfolio company of Ichor Therapeutics, announced the closure of $1.5 million in seed funding. The company will develop RPtag, a hyper-stable antibody mimetic scaffold published earlier this year in the peer-reviewed journal ACS Biochemistry, to take on conventional clinical antibody therapy as an orally bioavailable formulation. New high priority immunosenescence and …
James Peyer has been a scientist, entrepreneur, and advisor to biotechs and pharma companies, always with a specialization for developing new classes of therapeutics. James founded Apollo to support biotech entrepreneurs strategically, scientifically, and financially as they create the next generation of medicines. James Peyer received his PhD from the University of Texas Southwestern Medical …
David Sinclair and his team at Harvard Medical School claim to be able to reverse the aging of blood vessels and it restores youthful vitality. Using the synthetic precursors of two molecules naturally present in the body, the scientists also managed to reverse blood vessel demise and muscle atrophy in aging mice, boosting their exercise …