George Church talks about reversing human aging and claims they made mice live twice as long

George Church is developing better and better organs using pigs.

They are working to slow or reverse the aging in the organs to be used for transplant.

[about 8:40 in the video] He says the organ longvity has also been done successfully with entire mice. They have mice that live twice as long. He says he mean that if this were linear that humans could live 160 years.

[about 10:50 in the video] He says the reverse aging work being performed in dogs looks very promising.

The longest-lived vertebrate. One of the longest-lived vertebrates is this koi fish that lived 226 years.

They are learning about animal aging by sequencing naked mole rats and bowhead whales.


Making mice live twice as long would be huge. The best life extension of mice has been about 35% to 50% longer.

Oisin Biotechnology is clearing old cells

If the body still did not get rid of the substandard cells then work at Oisin Biotechnology and others would enable to bad cells to be cleared.

Oisin is extending the life of mice and has proven safety and improvement in monkeys. They will start human clinical trials in 2019.

Rejuvenate Bio has 60 aging reversal gene therapies. They have mentioned but not yet published eye popping results in mice. They are testing aging reversal in dogs in 2018-2019. Human treatments could be available on a general basis by 2025.

Rejuvenate Bio and Oisin Biotechnology have both indicated that they are successfully introducing genetic modifications to most of the cells of an adult organism with an injection. This change and delivery mechanism is not being blocked by the immune system.

Oisin Biotechnology is using Lipid-based delivery systems.

Oisin Biotech is safely delivering over 15 milligrams per kilogram of DNA plasmids encased in lipids. This is introduced in an injection. Each animal received a single dose. No antibody response in immune-competent mice, even at high doses.

Lipid nanoparticles are an established platform for in vivo drug delivery
• Improved protection
• Improved pharmacodynamics, biodistribution
• Tunable circulation time and targeting

Intracellular delivery is dependent upon cationic lipids
• Neutral liposomes (NL) have no charge, but are relatively poor at intracellular delivery
• Cationic liposomes (CL) have strong positive charge and deliver efficiently, but are highly toxic

They are introducing suicide genes into most of the cells of an adult mouse to trigger zombie senescent cells to die.

Oisin Biotech used single injections of LNP results in 75-90% reduction of prostate cancer tumor after 48 hours.

George Church’s Harvard plans to publish a scientific report on a technique that extends rodents’ lives by modifying two genes to act on four major diseases of aging: heart and kidney failure, obesity, and diabetes. According to Church, the results are “pretty eye-popping.”

Again the implication is that Rejuvenate Bio also have successful means to introduce genetic changes throughout the adult body of the mouse and probably in dogs.

Rejuvenate Bio has a pipeline of 60 genetic changes that they have identified as having the effect of reversing some aspect of aging.

Has Rejuvenate Bio identified all genetic aspects of aging? Probably not.

Could Rejuvenate Bio and Oisin Biotech and others introduce genetic modifications into adults to give most of the enhanced health and biology of supercentenarians (those who live over 110 years of age) and reverse major aspects of aging? It seems yes.

Could the techniques for in vivo genetic modifications be further improved and scaled up? This seems likely.

60 thoughts on “George Church talks about reversing human aging and claims they made mice live twice as long”

  1. this guy”” = George Church?Have you looked into his credentials before you call his opinion “”””suspicious””””?”””

    Reply
  2. You were being sarcastic about the “suspicious”? Need to use the [/sarc] delimiter, assuming Vuukle doesn’t delete that, too.

    Reply
  3. I’m a bit of a crank on this, I know, but I still think it might be workable to modify T. Gondi to be an efficient delivery mechanism for various interventions. Capable of moving through tissue, entering and leaving cells without killing them, can reach the brain without trouble. It would need some work to turn into a symbiont rather than parasite, but the potential is there.

    Reply
  4. You were being sarcastic about the suspicious””? Need to use the [/sarc] delimiter”” assuming Vuukle doesn’t delete that”” too.”””

    Reply
  5. I’m a bit of a crank on this I know but I still think it might be workable to modify T. Gondi to be an efficient delivery mechanism for various interventions. Capable of moving through tissue entering and leaving cells without killing them can reach the brain without trouble.It would need some work to turn into a symbiont rather than parasite but the potential is there.

    Reply
  6. Doubling the lifespan of a small short-lived mammal is less promising, because, no, it is probably NOT linear with mammal size and present lifespan. Extending their lifespan is low-hanging fruit, we humans have already been naturally selected for long lifespan, and making anymore gains there is a much greater challenge. Bowhead whales and naked mole-rats are probably a good pathway, especially the first. And do not forget long-lived birds, foremost parrots! I seldom see them mentioned in longevity studies, however, I think they are a treasure trove of longevity/anti-aging potential. The largest parrots weigh only 2.5-3 kg, but can live to 70-80 years, possibly even over 100, and with a high metabolism (and apparently mostly cancer free). Apparently these animals have found a way to mitigate senescence and genetic deterioration (cancer), while having a fast warm-blooded metabolism.

    Reply
  7. Doubling the lifespan of a small short-lived mammal is less promising because no it is probably NOT linear with mammal size and present lifespan. Extending their lifespan is low-hanging fruit we humans have already been naturally selected for long lifespan and making anymore gains there is a much greater challenge.Bowhead whales and naked mole-rats are probably a good pathway especially the first.And do not forget long-lived birds foremost parrots!I seldom see them mentioned in longevity studies however I think they are a treasure trove of longevity/anti-aging potential. The largest parrots weigh only 2.5-3 kg but can live to 70-80 years possibly even over 100 and with a high metabolism (and apparently mostly cancer free).Apparently these animals have found a way to mitigate senescence and genetic deterioration (cancer) while having a fast warm-blooded metabolism.

    Reply
  8. Perhaps waiting 50 years to get results could be the reason they do not try on those animals. Even if there is not a 100% increase in life span but say a 40% with health improvements in humans that would not be a failure.

    Reply
  9. Perhaps waiting 50 years to get results could be the reason they do not try on those animals. Even if there is not a 100{22800fc54956079738b58e74e4dcd846757aa319aad70fcf90c97a58f3119a12} increase in life span but say a 40{22800fc54956079738b58e74e4dcd846757aa319aad70fcf90c97a58f3119a12} with health improvements in humans that would not be a failure.

    Reply
  10. Perhaps waiting 50 years to get results could be the reason they do not try on those animals. Even if there is not a 100% increase in life span but say a 40% with health improvements in humans that would not be a failure.

    Reply
  11. Perhaps waiting 50 years to get results could be the reason they do not try on those animals. Even if there is not a 100{22800fc54956079738b58e74e4dcd846757aa319aad70fcf90c97a58f3119a12} increase in life span but say a 40{22800fc54956079738b58e74e4dcd846757aa319aad70fcf90c97a58f3119a12} with health improvements in humans that would not be a failure.

    Reply
  12. Perhaps waiting 50 years to get results could be the reason they do not try on those animals. Even if there is not a 100% increase in life span but say a 40% with health improvements in humans that would not be a failure.

    Reply
  13. Doubling the lifespan of a small short-lived mammal is less promising, because, no, it is probably NOT linear with mammal size and present lifespan. Extending their lifespan is low-hanging fruit, we humans have already been naturally selected for long lifespan, and making anymore gains there is a much greater challenge. Bowhead whales and naked mole-rats are probably a good pathway, especially the first. And do not forget long-lived birds, foremost parrots! I seldom see them mentioned in longevity studies, however, I think they are a treasure trove of longevity/anti-aging potential. The largest parrots weigh only 2.5-3 kg, but can live to 70-80 years, possibly even over 100, and with a high metabolism (and apparently mostly cancer free). Apparently these animals have found a way to mitigate senescence and genetic deterioration (cancer), while having a fast warm-blooded metabolism.

    Reply
  14. Doubling the lifespan of a small short-lived mammal is less promising because no it is probably NOT linear with mammal size and present lifespan. Extending their lifespan is low-hanging fruit we humans have already been naturally selected for long lifespan and making anymore gains there is a much greater challenge.Bowhead whales and naked mole-rats are probably a good pathway especially the first.And do not forget long-lived birds foremost parrots!I seldom see them mentioned in longevity studies however I think they are a treasure trove of longevity/anti-aging potential. The largest parrots weigh only 2.5-3 kg but can live to 70-80 years possibly even over 100 and with a high metabolism (and apparently mostly cancer free).Apparently these animals have found a way to mitigate senescence and genetic deterioration (cancer) while having a fast warm-blooded metabolism.

    Reply
  15. You were being sarcastic about the “suspicious”? Need to use the [/sarc] delimiter, assuming Vuukle doesn’t delete that, too.

    Reply
  16. You were being sarcastic about the suspicious””? Need to use the [/sarc] delimiter”” assuming Vuukle doesn’t delete that”” too.”””

    Reply
  17. I’m a bit of a crank on this, I know, but I still think it might be workable to modify T. Gondi to be an efficient delivery mechanism for various interventions. Capable of moving through tissue, entering and leaving cells without killing them, can reach the brain without trouble. It would need some work to turn into a symbiont rather than parasite, but the potential is there.

    Reply
  18. I’m a bit of a crank on this I know but I still think it might be workable to modify T. Gondi to be an efficient delivery mechanism for various interventions. Capable of moving through tissue entering and leaving cells without killing them can reach the brain without trouble.It would need some work to turn into a symbiont rather than parasite but the potential is there.

    Reply
  19. Doubling the lifespan of a small short-lived mammal is less promising, because, no, it is probably NOT linear with mammal size and present lifespan. Extending their lifespan is low-hanging fruit, we humans have already been naturally selected for long lifespan, and making anymore gains there is a much greater challenge.

    Bowhead whales and naked mole-rats are probably a good pathway, especially the first.

    And do not forget long-lived birds, foremost parrots!
    I seldom see them mentioned in longevity studies, however, I think they are a treasure trove of longevity/anti-aging potential. The largest parrots weigh only 2.5-3 kg, but can live to 70-80 years, possibly even over 100, and with a high metabolism (and apparently mostly cancer free).

    Apparently these animals have found a way to mitigate senescence and genetic deterioration (cancer), while having a fast warm-blooded metabolism.

    Reply
  20. this guy”” = George Church?Have you looked into his credentials before you call his opinion “”””suspicious””””?”””

    Reply
  21. I’m a bit of a crank on this, I know, but I still think it might be workable to modify T. Gondi to be an efficient delivery mechanism for various interventions. Capable of moving through tissue, entering and leaving cells without killing them, can reach the brain without trouble.

    It would need some work to turn into a symbiont rather than parasite, but the potential is there.

    Reply

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