George Church is developing better and better organs using pigs.
They are working to slow or reverse the aging in the organs to be used for transplant.
[about 8:40 in the video] He says the organ longvity has also been done successfully with entire mice. They have mice that live twice as long. He says he mean that if this were linear that humans could live 160 years.
[about 10:50 in the video] He says the reverse aging work being performed in dogs looks very promising.
The longest-lived vertebrate. One of the longest-lived vertebrates is this koi fish that lived 226 years.
They are learning about animal aging by sequencing naked mole rats and bowhead whales.
Making mice live twice as long would be huge. The best life extension of mice has been about 35% to 50% longer.
Oisin Biotechnology is clearing old cells
If the body still did not get rid of the substandard cells then work at Oisin Biotechnology and others would enable to bad cells to be cleared.
Oisin is extending the life of mice and has proven safety and improvement in monkeys. They will start human clinical trials in 2019.
Rejuvenate Bio has 60 aging reversal gene therapies. They have mentioned but not yet published eye popping results in mice. They are testing aging reversal in dogs in 2018-2019. Human treatments could be available on a general basis by 2025.
Rejuvenate Bio and Oisin Biotechnology have both indicated that they are successfully introducing genetic modifications to most of the cells of an adult organism with an injection. This change and delivery mechanism is not being blocked by the immune system.
Oisin Biotech is safely delivering over 15 milligrams per kilogram of DNA plasmids encased in lipids. This is introduced in an injection. Each animal received a single dose. No antibody response in immune-competent mice, even at high doses.
Lipid nanoparticles are an established platform for in vivo drug delivery
• Improved protection
• Improved pharmacodynamics, biodistribution
• Tunable circulation time and targeting
Intracellular delivery is dependent upon cationic lipids
• Neutral liposomes (NL) have no charge, but are relatively poor at intracellular delivery
• Cationic liposomes (CL) have strong positive charge and deliver efficiently, but are highly toxic
They are introducing suicide genes into most of the cells of an adult mouse to trigger zombie senescent cells to die.
Oisin Biotech used single injections of LNP results in 75-90% reduction of prostate cancer tumor after 48 hours.
George Church’s Harvard plans to publish a scientific report on a technique that extends rodents’ lives by modifying two genes to act on four major diseases of aging: heart and kidney failure, obesity, and diabetes. According to Church, the results are “pretty eye-popping.”
Again the implication is that Rejuvenate Bio also have successful means to introduce genetic changes throughout the adult body of the mouse and probably in dogs.
Rejuvenate Bio has a pipeline of 60 genetic changes that they have identified as having the effect of reversing some aspect of aging.
Has Rejuvenate Bio identified all genetic aspects of aging? Probably not.
Could Rejuvenate Bio and Oisin Biotech and others introduce genetic modifications into adults to give most of the enhanced health and biology of supercentenarians (those who live over 110 years of age) and reverse major aspects of aging? It seems yes.
Could the techniques for in vivo genetic modifications be further improved and scaled up? This seems likely.