New Gene Editing Tool for Millions of Edits

There is a new gene-editing tool called Retron Library Recombineering (RLR) that makes this task easier that has been developed by George Church and his team. RLR generates up to millions of mutations simultaneously, and “barcodes” mutant cells so that the entire pool can be screened at once, enabling massive amounts of data to be …

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Self-healing Fabric

A DNA construct is an artificially constructed segment of nucleic acid. It can be isolated or integrated in another DNA molecule. A recombinant DNA construct is produced by laboratory methods. Polynucleotide constructs with at least one disruption or tearing responsive promoter and at least one sequence encoding a fiber-forming protein. A cell with such constructs …

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Genome Editing Anti-cancer System

Researchers at Tel Aviv University have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer. The researchers developed a novel lipid nanoparticle-based delivery system that specifically targets cancer cells and destroys them by genetic manipulation. The system, called CRISPR-LNPs, carries …

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Meta DNA Revolutionizes DNA Nanotechnology By Scaling Up Size By 1000 to 1 Million Times

The new meta-DNA self-assembly concept may totally transform the microscopic world of structural DNA nanotechnology. Decades ago a huge milestone in DNA technology was the invention of DNA origami, where a long single-stranded DNA is folded into designated shapes with the help of hundreds of short DNA staple strands. DNA nanotechnology had challenges assembling larger …

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Self-replicating Anti-viral Molecular Machines

Augmanity, a research company based in Rehovot, Israel, has synthesized molecular machines, made from nucleic acids, which are capable of digesting viral RNA and utilizing it to assemble additional copies of itself inside living cells. The machine’s body plan combines several parts that build upon the target RNA, assembling an immobile, DNA:RNA 4-way junction, which …

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Molecular Electronics for 400 Times Faster DNA Reading by 2024

Roswell has deploying Molecular Electronics sensors on standard CMOS chip technology for a mass manufacturable and scalable platform. IMEC and Roswell have completed proof of concept work and are in the final development process. Commercial molecular biosensors will be available in 2021 for biosensing and DNA sequencing applications. Roswell will have rapid, low cost, mobile …

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Commercial Molecular Electronics Chips in 2021

Roswell Biotechnologies and IMEC are partnering to develop the first molecular electronics chips for disease surveillance, precision medicine and DNA storage. They are targeting 2021 for commercial molecular electronic chips. In 2018, IMEC and Candence taped out a 3 nanometer precision test chip. IMEC also has onchip fluid sensors and tiny sensors for internet of …

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2020 Emergency Coronovirus Treatment Will Start in 3 Months Versus 2 Years for SARS in 2003

In 2003 it took 20 Months for the first experimental treatment for newly identified virus but in 2020 it appears it will take 3 months for the first treatments against the Wuhan Coronavirus. China has already published the genome sequence of the Wuhan Coronavirus and experimental vaccines should be in human testing by April, 2020. …

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Electric Signal Detection from Single Molecules for Molecular Electronics Revolution

The barrier to molecular electronics was the previous inability to detect the tiny electric signals from single molecules. Roswell Biotechnologies overcame that problem and integrated the solution with CMOS. This enables an interface between molecules for sensors and DNA and other biological detections with CMOS. Nanopores have existed for a long time and being able …

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