4000 Times Fewer Gene Editing Errors Without Sacrificing Speed

Scientists at The University of Texas at Austin have redesigned a key component of a widely used CRISPR-based gene-editing tool, called Cas9, to be thousands of times less likely to target the wrong stretch of DNA while remaining just as efficient as the original version, making it potentially much safer. Other labs have redesigned Cas9 …

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The Far Future and Using Atomic Precision for the Next Level of Technology

Adam Brown (Stanford) and Robin Hanson (George Mason University) talk about some interesting intellectual concepts for the distant futures in the conference video below. Christine Peterson, Foresight Institute, talks about getting to the next level. She highlighted the need for molecular nanotechnology. Leveraging various forms of atomically precise capabilities are starting to reach interesting new …

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DNA, RNA Reading Just Got Thousands of Times Faster

DNA, RNA and protein reading just got thousands of times faster with the commercial release of Roswell Biotechnologies molecular electronics chip. The first molecular electronics chip has been developed. This is realizing a 50-year-old goal molecular nanotechnology to integrate single molecules into circuits to achieve the ultimate scaling limits of Moore’s Law. It was developed …

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A World With Cheap Aging Damage Reversal

What would a world with cheap aging damage reversal look like? This could happen with biotech or gene therapy injections that repair aging damage. Oisin Biotechnologies has been developing a highly precise, patent-pending, DNA-targeted intervention to clear these cells. There is also work by Rejuvenate Bio to create injectable combination gene therapy that could reverse …

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New Gene Editing Tool for Millions of Edits

There is a new gene-editing tool called Retron Library Recombineering (RLR) that makes this task easier that has been developed by George Church and his team. RLR generates up to millions of mutations simultaneously, and “barcodes” mutant cells so that the entire pool can be screened at once, enabling massive amounts of data to be …

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Self-healing Fabric

A DNA construct is an artificially constructed segment of nucleic acid. It can be isolated or integrated in another DNA molecule. A recombinant DNA construct is produced by laboratory methods. Polynucleotide constructs with at least one disruption or tearing responsive promoter and at least one sequence encoding a fiber-forming protein. A cell with such constructs …

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Genome Editing Anti-cancer System

Researchers at Tel Aviv University have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer. The researchers developed a novel lipid nanoparticle-based delivery system that specifically targets cancer cells and destroys them by genetic manipulation. The system, called CRISPR-LNPs, carries …

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Meta DNA Revolutionizes DNA Nanotechnology By Scaling Up Size By 1000 to 1 Million Times

The new meta-DNA self-assembly concept may totally transform the microscopic world of structural DNA nanotechnology. Decades ago a huge milestone in DNA technology was the invention of DNA origami, where a long single-stranded DNA is folded into designated shapes with the help of hundreds of short DNA staple strands. DNA nanotechnology had challenges assembling larger …

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Self-replicating Anti-viral Molecular Machines

Augmanity, a research company based in Rehovot, Israel, has synthesized molecular machines, made from nucleic acids, which are capable of digesting viral RNA and utilizing it to assemble additional copies of itself inside living cells. The machine’s body plan combines several parts that build upon the target RNA, assembling an immobile, DNA:RNA 4-way junction, which …

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