Three new alphacoronaviruses, three new betacoronaviruses, and one known alphacoronavirus previously identified in other southeast Asian countries were detected for the first time in bats in Myanmar. Studies in bats in China found over 400 coronaviruses. SARS-related viruses in these bat populations have the potential to go directly into human cells and do not need …
X-FDA Commissioner Scott Gottlieb and four other experts have published a roadmap to re-opening the US economy from Coronavisus shutdowns. Here Nextbigfuture reviews the details of the next phase. Trigger for Moving to Phase II A state can safely proceed to Phase II when it has achieved all the following: A sustained reduction in cases …
CanSino Biologics is starting phase II clinical trials for Ad5-nCoV, a COVID-19 vaccine candidate. Ad5-nCoV is a genetic engineered vaccine candidate with the replication-defective adenovirus type 5 as the vector to express SARS-CoV-2 spike protein, which intends to be used to prevent the disease caused by the novel coronavirus infection. In the phase 1 trial, …
Forfour years, MIGAL [The Galilee Research Institute] researchers has been developing a vaccine against infectious bronchitis virus (IBV), which causes a bronchial disease affecting poultry. The poultry coronavirus has high genetic similarity to the human COVID-19, and that it uses the same infection mechanism. This could be a lucky break for minor modification of the …
There is reports of 77 different Coronavirus clinical trial applications filed have been China. Other sources talking about 19 clinical trials registered in China. Two weeks ago there were an estimated 30 anti-coronavirus therapies in the pipeline. Researchers in China are launching more systematic tests of these repurposed medicines. Since January 28, scientists have registered …
1. U.S.-based biotech Gilead, known for its HIV and hepatitis C treatments, has partnered with Beijing’s China-Japan Friendship Hospital to test out an antiviral drug called remdesivir in actual humans in Wuhan, the apparent origin site of the coronavirus outbreak. 2. Thailand is verifying a treatment using three drugs. Large doses of the flu drug …
Doctors in Thailand combined the anti-flu drug oseltamivir with lopinavir and ritonavir, anti-virals used to treat HIV to cure a 71-year-old woman of coronavirus over a 48 hour period. Thailand’s Health ministry was awaiting research results to prove the findings. They have also stopped short of calling it a cure but it is a treatment. …
The Emergency Committee of the World Health Organization reports that China currently premlimary calculation of human-to-human transmission (R0) of coronavirus 2019 ncov is 1.4-2.5. HKU Medicine has released new nowcasting and forecasting estimates for the 2019-nCoV outbreak. They estimate that the current R0 is between 1.9 and 2.3, and that current case counts may be …
There has been 20 years of work on messenger RNA treatments against viruses. Technological advancements in RNA biology, chemistry, stability, and delivery systems have accelerated the development of fully synthetic mRNA vaccines. Molecular Therapy Journal (April 2019) reviewed mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases Vaccines – Enlisting the mRNA …
In 2003 it took 20 Months for the first experimental treatment for newly identified virus but in 2020 it appears it will take 3 months for the first treatments against the Wuhan Coronavirus. China has already published the genome sequence of the Wuhan Coronavirus and experimental vaccines should be in human testing by April, 2020. …
A nonthermal plasma reactor was able to inactivate or remove from the airstream 99.9% of a test virus, with the vast majority due to inactivation.