4000 Times Fewer Gene Editing Errors Without Sacrificing Speed

Scientists at The University of Texas at Austin have redesigned a key component of a widely used CRISPR-based gene-editing tool, called Cas9, to be thousands of times less likely to target the wrong stretch of DNA while remaining just as efficient as the original version, making it potentially much safer. Other labs have redesigned Cas9 …

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Colossal Will Recreate Woolly Mammoth’s in 4-6 Years to Preserve Permafrost

Colossal has $15 million in funding and has started a de-extinction project to resurrect the Woolly Mammoth – or more specifically a cold-resistant elephant with all of the core biological traits of the Woolly Mammoth. It will walk like a Woolly Mammoth, look like one, sound like one, but most importantly it will be able …

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CRISPR at Lightning Speeds

Researchers at Johns Hopkins University has developed a way to speed up the CRISPR-Cas9 gene-editing process by using light-sensitive nucleotides. They altered some of the guide RNA sequencing by adding light-sensitive nucleotides. Doing so prevented the guide from doing its job until light was applied. And once that light was applied, the binding took place …

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Many CRISPR Gene Editing Clinical Trials Underway

Human clinical trials are using CRISPR/Cas9 to combat cancer and blood disorders. In these tests, researchers remove some of a person’s cells, edit the DNA and then inject the cells back in, now hopefully armed to fight disease. Researchers are also set to see how CRISPR/Cas9 works inside the human body. In an upcoming trial, …

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Stem Cells That Will Not Be Rejected Will Bring Mass Produced Stem Cell Treatments

CRISPR-Cas9 gene-editing system has made pluripotent stem cells that are functionally “invisible” to the immune system which will prevent rejection of stem cell transplants. Universal stem cells can be produced that will work for everyone and there will not be the need for personalized stem cells. This will bring mass production of stem cells for …

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Salk Researchers Used Gene Therapy for Successful Antiaging

Salk Institute researchers have used CRISPR/Cas9 therapy to suppress aging, enhance health and extend life span in mice. Above – This image shows two mice of the same age with progeria. The larger and healthier mouse on the left received the gene therapy, while the mouse on the right did not. Credit: Salk Institute They …

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